Quantitative Pharmacology (QP) Network
Advancing clinical pharmacology, translational medicine and therapeutics through the application of quantitative principles for the benefit of patients and society.

Network News 
QP Network on Social Media
You are cordially invited to join the ASCPT QP Network LinkedIn Group. QP leadership is actively exploring using this group as a platform to communicate and disseminate information pertinent to ASCPT members involved in quantitative pharmacology.

Click here for more information.

LinkedIn Group 

Quantitative Pharmacology Network Hot Topics Initiative 
One of the primary goals of the Quantitative Pharmacology (QP) Network is to enhance the educational opportunities for members. Help further the “Hot Topic” communications and raise awareness of new tools and methods developing in quantitative pharmacology, news and views relevant to the discipline, emerging challenges and opportunities, topics of active scientific debate, etc. Suggest your topic via email to  or today!
Current QP Hot Topic Commentaries:
Therapeutic Drug Monitoring for MAbs: What Does the Future Hold?

A Collaborative Venture for Drug Toxicity Prediction

Brexit and Pharma

Potential of Pharmacometricians Beyond Quantitative Pharmacology: Future Looks Promising!
Quantitative Pharmacology Influence & Impact Initiative
Last year, under the visionary leadership of Anne Heatherington, PhD, the Impact & Influence Initiative was launched to highlight the impact of QP approaches in clinical pharmacology, translational medicine and therapeutics across the discovery, development, regulation and post-marketing applications.
The crowd-sourced compendium of impactful case-examples along with details speaker notes provided by the contributors to the QP Network at the recent ASCPT Annual Meeting and their contact information are now available: The QP Network invites you to contribute a case example. Click here further further information and an example case study
Upcoming Webinar
Title: Understanding the Impact of Quantitative Pharmacology (QP) in Drug Development Through Real-Life Examples
Presenters: Sophie Peigné & Marylore Chenel (Servier), Chunze Li & Sandhya Girish (Genentech) and Ulrika Simonsson (Uppsala University)
Description: The Impact and Influence Initiative of ASCPT was conceptualized in 2016 to highlight the clear and demonstrable impact of Quantitative Pharmacology (QP) through crowd-sourced examples which can be utilized by the members of the community to highlight and emphasize the critical role played by modeling and simulation in all aspects of drug discovery and development. Through this initiative, 37 high-impact examples were collated to exemplify the role of QP in various aspects of drug discovery and development, from early-stage to post-approval stage. In this webinar, we present 3 such impactful examples which show the critical role played of QP in impacting decisions in diverse areas of drug development, ranging from translational research to dose selection in special populations.
  • Example 1 – Modeling and Simulation for Clinical Studies in Pediatric Populations 
    Presenters – Sophie Peigné & Marylore Chenel (Servier)
    Model-based approach for initial ivabradine dose selection in pediatric population (6 months to 17 years) permitted to avoid safety issue in the youngest and the use of ineffective doses in the trials.
  • Example 2 – Dose Optimization of Kadcyla (T-DM1) in Patients with HER2-Positive Metastatic Breast Cancer 
    Presenters – Chunze Li & Sandhya Girish (Genentech)
    Quantitative analysis that included risk factors helped us understand our exposure response relationship for T-DM1 in HER2+ MBC patients and address the potential need for a dose optimization study in patients with low exposure.
  • Example 3 - Pre-Clinical to Clinical Forecasting in Tuberculosis Drug Development Using a Translational Pharmacometric Approach
    Presenter – Ulrika Simonsson (Uppsala University)
You must sign in as a member to access the recording below.
Past Webinars
*Please note you must be a member to access the recordings below.
Role of PK/PD Assessments at the Site of Action in Decision Making during the Development of Monoclonal Antibodies: Examples and Case Studies

A Genetic Algorithm Based Global Search Strategy for Population Pharmacokinetic/Pharmacodynamic Model Selection

A Six-Stage Workflow for Robust Application of Systems Pharmacology: A Conceptual Strategy and Case Study 

Network Goals

Scientific Expertise: 
The Quantitative Pharmacology Network brings together and advances quantitative disciplines across diverse backgrounds, including industry, academia and regulatory embracing new technology and approaches.

Catalyst for Innovation: 
The Quantitative Pharmacology Network fosters cutting-edge science in the areas of pharmacometrics and systems pharmacology, and knowledge around biologics, and supports (pre-competitive) collaborative efforts in these areas.

Influence and Impact:  
The Quantitative Pharmacology Network is the “go to” voice for the application of Quantitative Pharmacology to drug/biologics development and usage, and catalyzes broader awareness, education and adoption of these principles by scientists engaged in the complementary Networks.

Education and Communication: 
The Quantitative Pharmacology Network offers multiple educational opportunities and encourages submissions in the family of Journals as well as open dialogue among editors and members.

Organizational Effectiveness: 
The Quantitative Pharmacology Network has established a rhythm of business that supports its leadership using the ASCPT calendar as a guide and proactively develop future leaders.

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