Published on 5/1/2019 12:01:00 AM
Bridget L. Morse, PharmD, PhD, Research Scientist, Eli Lilly and Company, Indianapolis, IN
Dr. Morse first became involved with ASCPT in her interactions with the International Transporter Consortium (ITC), which is now the Membrane Transporter Community within the Society. Her favorite aspect of her membership is the availability of high‐quality research presented in the publications of the ASCPT Journal Family. Through the Annual Meeting and the journals, ASCPT has enabled a forum for scientists from different expertise, in vitro, preclinical, clinical pharmacology, and more. This forum has allowed these diverse scientists to learn from each other and has led to a more collaborative effort toward a mechanistic understanding of today's issues in discovery and development. For this reason she advises the younger generation to get involved with ASCPT as early as possible. She believes this is important, particularly for those in industry, as it can quickly become an issue to get too internally busy to benefit from the external interactions that ASCPT can offer.
In vitro to in vivo extrapolation (IVIVE) of drug transport is Dr. Morse's research focus. Specifically, she and her team are using physiologically‐based pharmacokinetic (PBPK) modeling to predict human pharmacokinetics and drug–drug interactions. Through these efforts, Dr. Morse is involved all the way from early discovery through development, from choosing the best clinical candidates to assessing drug–drug interactions. She believes that “through this modeling effort we can more accurately predict human dose, design clinical trials, and in particular cases even prevent trials from becoming necessary.” Currently, Dr. Morse is most heavily involved in the PBPK modeling of substrates that undergo hepatic transport; however, she has multiple ongoing projects that include assessment of drug transporter IVIVEs among all absorption, distribution, metabolism, and excretion characteristics.
Dr. Morse joined ASCPT in 2016. She has served as an abstract reviewer for the Annual Meeting.