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ASCPT Members-Only Webinar presented by the Regulatory Science (RS) Community and Membrane Transporter (MT) Community

Author: [AUTHOR] Published on 6/20/2019 12:52:00 PM

ASCPT Members-Only Webinar presented by the Regulatory Science (RS) Community and Membrane Transporter (MT) Community
Title: Intestinal OATP-Mediated Drug Interactions: Where Are We?
Date and Time: Monday, July 29, 2019, 1:00 pm ET
Speaker: Zhu Zhou, PhD, Maciej Zamek-Gliszczynski, PhD, and Xinning Yang, PhD
Moderator: Elimika Pfuma Fletcher, PharmD, PhD
Description: Considerable progress has been made in understanding the role of intestinal efflux transporters in drug absorption, and some of them (P-gp and BCRP) have been routinely studied to assess drug-drug interaction (DDI) liability. However, much less attention has been paid to intestinal uptake transporters, although an increasing number of drug interactions have been attributed to the inhibition of uptake transporters, particularly OATP2B1. Specific recommendations on how these transporters should be evaluated are currently lacking. The aim of this webinar is to present the current state of the art in intestinal OATP DDIs and foster discussion on the need and timing to evaluate these DDIs during drug development.
Registration Link: https://attendee.gotowebinar.com/register/127924179471419395

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