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ASCPT & FDA William B. Abrams Award Lecture

The William B. Abrams Lecture is a joint educational initiative of ASCPT and the FDA. The lecture series, supported in part by The Merck Company Foundation, was established in 1999 to honor William B. Abrams, MD, an ASCPT president from 1975 to 1976.

Among his many accomplishments, Dr. Abrams worked at the FDA as the first special government employee to establish the Center for Drug Evaluation and Research Staff College and develop its curriculum. He also had a distinguished career in the pharmaceutical industry as a longtime employee of Merck Research Laboratories.

For more than 10 years, ASCPT and the FDA have invited experts from academia, industry, and government to discuss advances in clinical pharmacology and drug development. These scientists have excelled in their specialty areas and are some of the most highly esteemed clinical pharmacologists in the field. Their presentations convey novel information and perspectives on fundamental aspects of clinical pharmacology. Previous lectures have included speakers from the Mayo Clinic, University of California, Children's Mercy Hospitals and Clinics, and the National Institutes of Health.
Please click here for a list of previous winners.

2020 ASCPT & FDA William B. Abrams Lecture

ASCPT FDA Abrams M Relling
The 2020 ASCPT & FDA William Abrams Lecture Award recipient is Mary V. Relling, PharmD from St. Jude's Children's Research Hospital.

Clinical Implementation of Pharmacogenetics
View the recording: Members can access the recording of the lecture in the ASCPT Online Library

Lecture Description: There are few select examples in pharmacogenetics for which the evidence from published research is already strong enough to support the use of genetic testing in the clinic. Pharmacogenetic testing in routine clinical care remains uncommon; one reason has been that the processes needed to move from genetic test results to specific prescribing recommendations have been unclear. This course will provide an overview of the Clinical Pharmacogenetics Implementation Consortium (CPIC®), developed in 2009, to write, curate, and update freely available, peer-reviewed, and detailed gene/drug pharmacogenetic clinical practice guidelines with accompanying computational tables to facilitate the appropriate use of pharmacogenetic tests in clinical care. In addition, the course will discuss implementation of the CPIC guidelines in a clinical protocol at St. Jude’s, PG4KDS, with an aim to preemptively test all eligible children at the institute and implement all CPIC guidelines by placing test results, with the necessary clinical decision support tools to guide prescribing, in an electronic health record. The rationale for preemptive testing is that the lifetime use of pharmacogenetically actionable drugs is high, almost all patients have at least one actionable genotype, and the cost of preemptively testing all pharmacogenetically actionable genes is low. For PG4KDS, over 5500 patients have been enrolled, and St. Jude has clinically implemented 12 genes and > 35 drugs: TPMT and NUDT15 for thiopurines; CYP2D6 for opiates, antidepressants, and ondansetron; CYP2C19 for voriconazole, clopidogrel, proton pump inhibitors and tricyclics; DPYD for fluoropyrimidines; UGT1A1 for atazanavir; SLC01B1 for simvastatin; CYP3A5 for tacrolimus; CYP2C9 for celecoxib; mt-RNR1 and aminoglycosides; RYR1/CACNA1S and anesthetics.

References: Learning Objectives:
  • Discuss the rationale for development and the purpose of the CPIC guidelines
  • Demonstrate the practical utility of the CPIC guidelines in a clinical protocol
If you have any questions about the ASCPT & FDA Abrams Award please contact Megan McBeath Hay

Continuing Education Credit
In support of improving patient care, this activity has been planned and implemented by the FDA Center for Drug Evaluation and Research and the American Society for Clinical Pharmacology and Therapeutics. The FDA Center for Drug Evaluation and Research is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

This activity was planned by and for the healthcare team, and learners will receive 1 Interprofessional Continuing Education (IPCE) credit(s) for learning and change.

CME: FDA Center for Drug Evaluation and Research designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CPE: This knowledge-based activity has been assigned ACPE Universal Activity Number JA0002895-0000-20-042-L04-P for 1.00 contact hour(s).

CNE: FDA Center for Drug Evaluation and Research designates this activity for 1.00 contact hour(s).

Requirements for Receiving CE Credit
Physicians, pharmacists, nurses, and those claiming non-physician CME: participants must attest to their attendance and complete the final activity evaluation via the CE Portal. For multi-day activities, participants must attest to their attendance and complete the faculty evaluation each day. Final activity evaluations must be completed within two weeks after the activity - no exceptions.

Pharmacists will need their NABP e-profile ID number as well as their DOB in MMDD format in order to claim CE credit.

Important Note regarding completion of evaluations and receiving credit:
Attendees have 14 days from the last day of the activity to log in, complete the required evaluation(s) and attest to your attendance to claim credit. Physicians and nurses may then view/print statement of credit. Pharmacists should log into the CPE monitor 10 weeks after the last session of the activity to obtain their CE credit.

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