Upcoming Webinars:

ASCPT Journal Family Webinar
Title: Changes in Expression and Activity of Transporters in Disease: Do They Impact Pharmacokinetics and Toxicity of Drugs?
Date and Time: November 29, 2018 12:00 PM EST
Speakers: Raymond Evers, PhD, and Jason Sprowl, PhD
Moderator: Saskia de Wildt, MD, PhD
Description: Transporters play a critical role in the ADME of many drugs and endogenous compounds. Disruption of these pathways can have a profound effect on overall physiology, or drug pharmacokinetics, efficacy, and toxicity. Join Drs. Evers and Sprowl as they provide an overview of changes in transporter function associated with acute and chronic disease states, and regulatory pathways affecting transporter expression. In addition, they will discuss how mechanistic understanding in the role of transporters in drug disposition can aid in alleviating transporter-mediated toxic effects.
Registration Link: https://attendee.gotowebinar.com/register/5869984011849709313

ASCPT Journal Family Webinar
Title: 2018 ITC Update on Clinically-Relevant Transporters, Clinical Probes, and DDI Evaluation
Date and Time: December 7, 2018 12:00 PM EST
Speakers: Maciej Zamek-Gliszczynski, PhD
Moderator: Shuiying Hu, PhD
Description: Join this ASCPT Journal Family webinar as Maciej Zamek-Gliszczynski, PhD summarizes the state-of-the-art in transporters in drug development based on four recent ITC whitepapers recently published in Clinical Pharmacology & Therapeutics (Vol 104, Iss 5). A practical overview of emerging transporters of clinical relevance will be provided (e.g., OCT1, OATP2B1, etc.). Best practice in design of clinical DDI studies will be illustrated with recent advances in the study of OCT1, P-gp, and BCRP. Lastly, considerations for optimal selection of clinical probe drugs, including future potential utility of transporter biomarkers, will be discussed.
Registration link: https://attendee.gotowebinar.com/register/4318986521719019011 

Past webinars:

Title	Speaker(s)	Recording and/or Presentation Slides	Primary Audience
Endogenous Biomarkers of Membrane Transporters and Model Based Prediction of Clinic	Kenta Yoshida, PhD Xinning Yang, PhD	Webinar Recording	PSP Journal
ASCPT Abstracts – Everything You Need to Know	Kellie Schoolar Reynolds, PharmD	Webinar Recording Webinar Transcript	Annual Meeting
Member Orientation Webinar Sponsored by Cytel	Jin Yan Jin, PhD	Webinar Recording	ASCPT New Members
New Member Welcome	Jin Yan Jin, PhD	Webinar Recording Presentation Slides	ASCPT New Members
2018 Scientific Proposals - Secrets to Success	Virginia (Ginny) D. Schmith, PhD, FCP	Webinar recording Presentation Slides	ASCPT Members
New Member Welcome Webinar for 2017 Annual Meeting Attendees	Jin Yan Jin, PhD	Webinar Recording Presentation Slides	New ASCPT Members
How to Participate in the ASCPT 2017 Annual Meeting		Webinar Recording	Membrane Transporter
Model Evaluation of Continuous Data Pharmacometric Models: Metrics and Graphics	France Mentré	Webinar Recording	ASCPT Journal Family
Driving Patient-Centered Translational Medicine	Christopher P. Austin, MD	Webinar Recording	ASCPT Journal Family
Implementing Pharmacogenetic Tests for Patient Care Using Clinical Pharmacogenetics Implementation Consortium (CPIC®) Guidelines	Mary V. Relling, PharmD	Webinar Recording	ASCPT Journal Family
Journal Club "Comparison of Genome Sequencing and Clinical Genotyping for Pharmacogenes"	Wenjian Yang	Webinar Recording *presentation only, no audio Presentation slides	Pharmacogenomics
Pharmacokinetics and Dose Adjustments for Monoclonal Antibodies in IBD - Considerations and Applications in Clinical Practice	Diane Mould, PhD Anne Strik, MD	Webinar Recording Presenters' responses to attendee questions	ASCPT Journal Family

For all past webinars please visit the ASCPT Webinar Library.

Upcoming Webinars:

ASCPT Members-Only Webinar Presented by the Pharmacogenomics Community (PGx)
Title: Functional annotation of variants of uncertain significance
Date and Time: 2:00 PM EST, Monday, December 10, 2018 
Speakers: Dr. Kiran Musunuru
Moderator: Dr. Sonal Singh
Description: The presentation will describe an approach based on induced pluripotent stem cells (iPSCs) to functionally annotate variants of uncertain significance in cardiomyopathy-associated genes. The platform makes use of CRISPR-Cas9 and other gene-editing tools to rapidly insert or correct patients’ variants in iPSCs, followed by differentiation of the iPSCs into cardiomyocytes in a dish. Various properties of these cardiomyocytes—such as morphological and electrophysiological characteristics—can provide insight into whether the variants are benign or pathogenic. The approach has been used for annotation of patients’ variants in TNNT2 and LMNA and has been developed to the point that it can be used to inform patient management in real time. A specific example regarding a 65-year-old woman with hypertrophic cardiomyopathy and a variant of uncertain significance in TNNT2, which was successfully annotated between her first and second clinic visits and had implications for cascade genetic testing of her children and grandchildren, will be highlighted.
Registration: https://attendee.gotowebinar.com/register/5191457794941374978

For all past webinars please visit the ASCPT Webinar Library.