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ASCPT 2018 Annual Meeting
Biologics and Biomarkers & Translational Tools (BTT) Joint Community Meeting
FRIDAY, MARCH 23, 2018, 8:00 am-9:00 am
Room: Florida 1/2
This session will include a Community business discussion and programming ideas and feature two scientific presentations, "Intra Tumor Analysis of Trastuzumab Distribution by PID Staining, Breakthrough Method with High Visuality and Single Cell Quantification" and "Improved Prediction of Infliximab Clearance Using Erythrocite Sedimentation Rate and Anti-Infliximab Antibody Levels in Pediatric Patients with Inflammatory Bowel Disease."
Joint Systems Pharmacology and Biomarkers & Translational Tools Community Webinar
: Quantitative Systems Pharmacology (QSP) Modeling of Drug-Induced Nephrotoxicity – Bridging the Link Between Drug Exposure, Urinary Biomarkers and Renal Dysfunction
Date and Time
: Friday, February 16, 2018, 12:00 pm ET
: Yeshitila Gebremichael, PhD, Scientist, DILIsym Services., Inc.
: Richard Graham, PhD, Senior Director, Theravance Biopharma and BTT Community Chair
: Drug-induced nephrotoxicity is a challenging problem in both drug development and clinical treatment of critically ill patients. Detecting the potential for nephrotoxicity early in the drug development process is vital for safe development and dosing of therapies. Many novel urinary biomarkers that are injury-specific and more sensitive than traditional biomarkers have been identified recently, whereas interpretation remains challenging. Furthermore, a quantitative framework that links biomarkers signals to underlying cellular injury and renal dysfunction is lacking. Such framework plays a crucial role in safe drug development and clinical treatment. By coupling observations from preclinical urinary biomarkers and histopathology data with cell biology, renal physiology, and the physiologic processes involved in biomarker expression, we developed a multiscale quantitative systems pharmacology (QSP) model of drug-induced acute kidney injury.