ASCPT 2018 Annual Meeting
Systems Pharmacology (SP) and Oncology (ONC) Joint Community Meeting
THURSDAY, MARCH 22, 2018, 2:00 pm-3:00 pm
Room: Florida 1/2
To fully realize the opportunities for mechanistic, model informed oncology drug development, the SP and ONC Communities will present a cross-disciplinary discussion. Learning objectives of this joint meeting include: review of 2017 accomplishments and forecast of 2018 activities, identification of areas of shared interest, and solicitation of feedback regarding programming.
Joint SP and BTT Community Webinar
: Quantitative Systems Pharmacology (QSP) Modeling of Drug-Induced Nephrotoxicity – Bridging the Link Between Drug Exposure, Urinary Biomarkers and Renal Dysfunction
Date and Time
: Friday, February 16, 2018, 12:00 pm ET
: Yeshitila Gebremichael, PhD, Scientist, DILIsym Services., Inc.
: Richard Graham, PhD, Senior Director, Theravance Biopharma and BTT Community Chair
: Drug-induced nephrotoxicity is a challenging problem in both drug development and clinical treatment of critically ill patients. Detecting the potential for nephrotoxicity early in the drug development process is vital for safe development and dosing of therapies. Many novel urinary biomarkers that are injury-specific and more sensitive than traditional biomarkers have been identified recently, whereas interpretation remains challenging. Furthermore, a quantitative framework that links biomarkers signals to underlying cellular injury and renal dysfunction is lacking. Such framework plays a crucial role in safe drug development and clinical treatment. By coupling observations from preclinical urinary biomarkers and histopathology data with cell biology, renal physiology, and the physiologic processes involved in biomarker expression, we developed a multiscale quantitative systems pharmacology (QSP) model of drug-induced acute kidney injury.
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