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Systems Pharmacology (SP) Community

Community Goals

Scientific Expertise:
  • This Community is a resource for best practices in Systems Pharmacology through ‘state-of-the-art’ communication and compendium of current case examples, and through contributions to Annual Meeting programming and educational opportunities.
Catalyst for Innovation:
  • The Systems Pharmacology Community is implementing a ‘hot topics’ forum listing emerging and novel methods for collaborative Community development. This forum will be hosted on the ASCPT Systems Pharmacology Community site and/or other social media site(s).
Influence and Impact:
  • Our Community is initiating a compendium of clinical systems pharmacology case examples with impact statements describing how each has influenced clinical and/or regulatory-focused decisions. This compilation will include solicitation from the Community members and a literature review with a potential ‘hot topics’ forum as necessary.
Education and Communication:
  • Our Community is developing an inventory of the current ‘state-of-the-art’ in Systems Pharmacology to identify areas of need as training & communication opportunities, e.g., model development and qualification standards. We also continue to develop educational opportunities around subjects identified by members of our Community.
Organizational Effectiveness:
  • We are establishing a Systems Pharmacology Community Steering Committee (SC) membership along with general roles & expectations necessary to align our contributions with other Community goals. We are also establishing timings for communication outreach to Community members to announce key dates and news updates.

Upcoming Webinar
ASCPT Members-Only Webinar presented by the Systems Pharmacology (SP) and Early Career (EC) Communities
Title: Next Generation Pharmacometricians – Examples from Early Career Modelers on MID3 Implementation
Date and Time: Thursday, January 30, 2020, 1:00 pm ET
Speakers: Lulu Chu, and Songmao Zheng
Moderator: Aline Barth and Michael Block
Description: By means of using case studies, early career modelers will demonstrate how they developed the technical and soft skills to successfully implement modeling approaches and to impact discovery and drug development strategies. The presenters will reflect on the questions that had to be addressed during the modeling, the challenges they experienced, and how they successfully advocated, communicated and implemented MID3 at an early stage of their careers.
Registration Link: 
https://zoom.us/webinar/register/WN_uMvmxDqmTTG8wE1snuyn1g

ASCPT Members-Only Webinar presented by the Biologics Community, Pharmacometrics & Pharmacokinetics Community (PMK), Systems Pharmacology Community (SP), and Biomarkers & Translational Tools (BTT) Communities
Title: Clinical Pharmacology Considerations in Development of siRNA Therapeutics: Case Study of Givosiran
Date and Time: Tuesday, April 21, 2020, 1:00 pm ET
Speakers: Sagar Agarwal, PhD and Varun Goel, PhD
Moderator: Sagar Agarwal, PhD
Description: Small interfering RNAs (siRNAs) are a promising type of RNA-based therapeutic oligonucleotide drugs that can inactivate several target RNA molecules in a sequence-specific manner. Since the discovery of RNA interference (RNAi), a significant progress has been made in the development of therapeutic siRNAs including approval of the first ever siRNA therapy. Givosiran is a FDA approved siRNA therapeutic for the treatment of acute hepatic porphyria. Givosiran which is administered subcutaneously utilizes a GalNAc conjugate technology to enable targeted delivery to liver, the site of action. This presentation will give an overview of the clinical pharmacology program of givosiran, that included characterization of the PK and PD of givosiran, the impact of extrinsic and intrinsic factors, as well as special populations. Modeling and simulation analysis that enabled dose selection will be discussed.
Registration Link: 
hhttps://zoom.us/webinar/register/WN_idlcGg4PRsOVGKc0H3A1Rw

Past Webinars
Community Announcement
Do you have lab-meetings and learning tutorials in-house in your academic group, company or your neighborhood? Do you know that not all institutes have the same critical mass of pharmacometric experts as yours? The Pharmacometrics StudyGroups, an iniative of the International Society of Pharmacometrics (ISoP), is a platform to share your learning experiences with peers all around the world. Turn those in-house lab meetings to global knowledge and skill sharing opportunities! Learn more here.

Michael Block, PhD

Community Chair

 

Jason Chan, PhD

Community Vice Chair

 

Daniel Kirouac, PhD, PEng

Community Past Chair

 

Steering Committee Members:

Jason Chan, PhD
Lulu Chu, PhD
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