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Pharmacometrics & Pharmacokinetics (PMK) Community

The Pharmacometrics & Pharmacokinetics (PMK) Community represents a diverse group of scientists from pharmaceutical industry, government, and academia who are interested in the science of clinical pharmacology, pharmacokinetics/pharmacodynamics (PK/PD) and pharmacometrics as disciplines to spur the research and development of safe and effective therapeutics.

The mission of the PMK Community is to promote interaction and knowledge sharing of novel application of clinical pharmacology, PK/PD and pharmacometric approaches that can be utilized to accelerate drug discovery and development of innovative new medicines. We accomplish our mission by:
  • Education: Educational and knowledge sharing platforms on trending topics (e.g., new modalities, advanced analytics, real-world data, etc.) in clinical pharmacology, PK/PD and pharmacometrics via ASCPT’s Annual Meeting and webinars. This helps to enhance and accelerate the decision making in drug development.
  • Engagement: Promoting the engagement of Community members through collaboration, volunteer, and outreach opportunities. These efforts stimulate the connection among diverse PMK members and further grow the PMK Community.
  • Collaboration: Stimulating collaboration between the PMK Community and other ASCPT Communities (e.g., Regulatory Science, Biologics, Oncology) to advance the field of pharmacometrics, PK/PD and clinical pharmacology.

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Upcoming Webinar
ASCPT Members-Only Webinar Presented by the Oncology (ONC) and Pharmacometrics & Pharmacokinetics (PMK) Communities
Title: A Semi-Mechanistic PK/PD Model to Project Undetectable Minimal Residual Disease Rates in Chronic Lymphocytic Leukemia Studies
Date and Time: Tuesday, May 11, 2021, 12:00 pm EST
Speakers: Sathej Gopalakrishnan, PhD, and Ahmed H. Salem, PhD
Moderators: Deanna Brackman, PhD, and Neeraj Gupta, PhD
Description: Understanding the kinetics of minimal residual disease (MRD) in chronic lymphocytic leukemia (CLL) is an important aspect during the development of fixed duration targeted therapies. This webinar will introduce the clinical implications of MRD for the treatment of CLL and will include broader discussions on both MRD as an endpoint in hematological malignancies as well as the PK/PD modeling concepts utilized.

Additionally, the presenters will speak about the objective to develop, qualify, and utilize a semi-mechanistic PK/PD model to evaluate the impact of venetoclax-rituximab combination therapy on the kinetics of MRD in CLL patients. Such fit-for-purpose models have great potential in assisting clinical development of targeted therapies in hematologic oncology. Attend the session to learn more about the development of the model and how the findings and concepts provide the framework for applying similar models to drug development in all hematological malignancies and would provide substantial impact, especially on the topic of predicting sustained response that may allow for fixed duration therapies.
Register Now!

ASCPT Members-Only Webinar Presented by the Pharmacometrics & Pharmacokinetics (PMK) and Early Career (EC) Communities
Title: Introduction of Deep Learning in Drug Discovery and Development, Part 2: Artificial Neural Networks (ANNs)
Date and Time: Friday, May 14, 2021, 1:00 pm EST
Speakers: Patrick Lang and Jagdeep Podichetty, PhD
Moderator: Sakshi Sardar, PhD
Description: Artificial Neural Networks (ANNs) are algorithms that are inspired by the biological neural networks present in our brains. They consist of neurons grouped into input layers, hidden layers, and output layers. These networks take in raw data and learn to perform tasks over many iterations. In this webinar, we will build off Part 1 of the Introduction to Deep Learning in Drug Discovery and Development series, diving deeper into the framework for an ANN model. More specifically, we will go over the workflow of building an ANN and the steps involved. This webinar will also discuss evaluating model performance and optimization. Finally, we will showcase an ANN model built from scratch to identify handwritten digits.
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ASCPT Pharmacometrics & Pharmacokinetics (PMK) Community Members-Only Webinar
Title: Marrying Real-World Data and Modeling: A Case of Interdisciplinary MIDD to Address Changes of Bone Mineral Density in Premenopausal Women
Date and Time: Monday, May 24, 2021, 2:00 pm EST
Speaker: Mohamad Shebley, PhD
Moderators: Neeraj Gupta, PhD, and Akshanth Polepally, PhD
Description: This webinar will introduce the concept of interdisciplinary model-informed drug development (i-MIDD) in a real drug development setting. The presented work will describe how real-world data (RWD) could be linked to traditional pharmaco-statistical modeling to bridge understanding of long-term bone safety in premenopausal women. The work will highlight how the RWD could be extended to epidemiological modeling for evaluating clinical relevance of the projected changes in bone mineral density (BMD) in relation to future risk of bone fractures. For additional information, please click the registration link below.
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Past Webinars

Chunze Li, PhD

Community Chair

 

N Gupta

Neeraj Gupta, PhD

Community Vice Chair

 

Sreeneeranj Kasichayanula, PhD

Community Past Chair

 

Steering Committee

Chunze Li, PhD (Committee Chair)
Neeraj Gupta, PhD (Committee Vice Chair)
Xiaoying Chen, PhD
Robert Bies, PhD
Bilal AbuAsal, PhD
Akshanth Polepally, PhD
Nadia Terranova, PhD
Sagar Bachhav, PhD
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