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Quantitative Pharmacology (QP) Network

Network Goals

Scientific Expertise:
  • The Quantitative Pharmacology Network brings together and advances quantitative disciplines across diverse backgrounds, including industry, academia, and regulatory embracing new technology and approaches.
Catalyst for Innovation:
  • The Quantitative Pharmacology Network fosters cutting-edge science in the areas of pharmacometrics and systems pharmacology, and knowledge around biologics, and supports (pre-competitive) collaborative efforts in these areas.
Influence and Impact:
  • The Quantitative Pharmacology Network is the “go to” voice for the application of Quantitative Pharmacology to drug/biologics development and usage, and catalyzes broader awareness, education and adoption of these principles by scientists engaged in the complementary Networks.
Education and Communication:
  • The Quantitative Pharmacology Network offers multiple educational opportunities and encourages submissions to the ASCPT Journal Family as well as open dialogue among editors and members.
Organizational Effectiveness:
  • The Quantitative Pharmacology Network has established a rhythm of business that supports its leadership using the ASCPT calendar as a guide and proactively develop future leaders.

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Upcoming Community Webinars
ASCPT Members-Only Webinar presented by the Biologics Community
TitleDevelopment of Talimogene Laherparepvec, First FDA Approved Genetically Modified Oncolytic Virus: Perspectives of Clinical Pharmacology
Date and Time: Tuesday, October 29, 2019, 2:00 pm ET
Speakers and Panelists: Matt Hsu, PhD, Sumita Bhatta, MD, and Xiaofei Wang, PhD
Moderators: Yow-Ming Wang, PhD
Description: Talimogene laherparepvec is an oncolytic virus-based therapeutic product that is derived from herpes simplex virus type 1 (HSV-1). It has been genetically modified to efficiently replicate within tumors and to enhance systemic antitumor immune responses by producing the immune stimulatory protein granulocyte-macrophage colony-stimulating factor (GM-CSF). Clinical pharmacology program of talimogene laherparepvec was designed to characterize the kinetics of viral clearance through biodistribution in the blood and urine, shedding from injected tumors and exterior of the dressing, anti-HSV-1 seroconversion, and GM-CSF expression in tumor tissue and serum. This special presentation will provide an introduction of genetically modified products and regulatory advances in this field, as well as challenges and clinical pharmacology support of talimogene laherparepvec development pathway.
Registration Link: 
https://attendee.gotowebinar.com/register/2000518926673682691
Past Webinars
Quantitative Pharmacology Network Hot Topics Initiative
One of the primary goals of the Quantitative Pharmacology Network is to enhance the educational opportunities for members. Help further the “Hot Topic” communications and raise awareness of new tools and methods developing in quantitative pharmacology, news and views relevant to the discipline, emerging challenges and opportunities, topics of active scientific debate, etc. Suggest your topic via email to agrawal.scientist@gmail.com or hhassan@rx.umaryland.edu today! Current Quantitative Pharmacology Hot Topic Commentaries:
Quantitative Pharmacology Influence & Impact Initiative
Under the visionary leadership of Anne C. Heatherington, PhD, the Impact & Influence Initiative was launched to highlight the impact of Quantitative Pharmacology approaches in clinical pharmacology, translational medicine and therapeutics across the discovery, development, regulation and post-marketing applications. The crowd-sourced compendium of impactful case-examples along with detailed speaker notes provided by the contributors to the Quantitative Pharmacology Network at the ASCPT 2017 Annual Meeting and their contact information are now available: On behalf of the ASCPT Quantitative Pharmacology Network, we would like to again invite you to contribute to a new case study for the Influence and Impact Initiative that broadly highlights the impact of Quantitative Pharmacology in discovery and development strategy making, as well as in regulatory and post-marketing decision making. The aim of the initiative is to build upon the first version of the crowd-sourced compendium repository with new state-of-the-art quantitative pharmacology applications to increase awareness, advocacy for and education in applied Quantitative Pharmacology sciences. In addition, the initiative aims to detect advances and new trends in the field.

If you would like to contribute, please let us know your interest by April 17, 2019, by sending an email with the title for your case study to Aline Barth, PhD, or Akshanth Polepally, PhD. Draft case studies and speaker notes would be due May 31, 2019.

 

Sandra Visser, PhD

Network Chair

 

Ryan Funk, PharmD, PhD

Network Vice Chair

 

Sriram Krishnaswam, PhD, FCP

Network Past Chair

 

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