ASCPT 2018 Annual Meeting
Translational & Precision Medicine (TPM) Network Meeting
WEDNESDAY, MARCH 21, 2018, 1:00 pm-3:00 pm
Room: Florida 5
Join the TPM Network for a brief business meeting followed by two talks: "Genome-Wide Association Study of Antipsychotic Pharmacokinetics
," present ed by Kristin L. Bigos, PhD, and "Precision Medicine with Indigenous People
," presented by Erica Woodahl, PhD. The meeting will close with a discussion and programming strategy session and a presentation on "What's Next on the Horizon in Precision Medicine
," presented by Kelly E. Dooley, MD, PhD, and Matthew L. Rizk, PhD.
Upcoming Community Webinars
Joint Systems Pharmacology and Biomarkers & Translational Tools Community Webinar
: Quantitative Systems Pharmacology (QSP) Modeling of Drug-Induced Nephrotoxicity – Bridging the Link Between Drug Exposure, Urinary Biomarkers and Renal Dysfunction
Date and Time
: Friday, February 16, 2018, 12:00 PM EST
: Yeshitila Gebremichael, PhD, Scientist, DILIsym Services., Inc.
: Richard Graham, PhD, Senior Director, Theravance Biopharma and BTT Community Chair
: Drug-induced nephrotoxicity is a challenging problem in both drug development and clinical treatment of critically ill patients. Detecting the potential for nephrotoxicity early in the drug development process is vital for safe development and dosing of therapies. Many novel urinary biomarkers that are injury-specific and more sensitive than traditional biomarkers have been identified recently, whereas interpretation remains challenging. Furthermore, a quantitative framework that links biomarkers signals to underlying cellular injury and renal dysfunction is lacking. Such framework plays a crucial role in safe drug development and clinical treatment. By coupling observations from preclinical urinary biomarkers and histopathology data with cell biology, renal physiology, and the physiologic processes involved in biomarker expression, we developed a multiscale quantitative systems pharmacology (QSP) model of drug-induced acute kidney injury.
To register, please visit the Biomarkers & Translational Tools community page
Joint Infectious Diseases and Global Health Community Webinar
Title: Breaking Down Barriers for Acceleration of Development of New Anti-Infectives
Date and Time: Wednesday, February 21, 2018, 1:00 PM EST
Speakers: Major Jeffrey W. Froude, II, PhD, Uniformed Services University of the Health Sciences and Steven E. Kern, PhD, Bill and Melinda Gates Foundation
Moderators: Kelley E. Dooley, MD, PhD, Johns Hopkins University School of Medicine, and Matthew Rizk, PhD, Merck
Organizer: Hazem Hassan, PhD, MS, RPh, RCDS, University of Maryland School of Pharmacy
Description: This webinar will focus on the integrated research and development methods utilized by the Department of Defense for acquiring medical countermeasures. Major Jeff Froude will discuss historical success of the therapeutic developments by DTRA during the Ebola outbreak and how these lessons learned can be utilized in the future for both defense threats as well as global health countermeasure development. Dr. Kern will discuss how the Gates Foundation is working with their partners to use model-informed drug development techniques to advance the development of anti-infective agents in global health. With specific emphasis on malaria, tuberculosis, and other neglected diseases, this section will highlight challenges to new drug development for these conditions and opportunities being implemented that address these challenges and improve the potential for creating successful therapeutic solutions.
Registration Link: https://register.gotowebinar.com/register/3791315492349279233