Author: [AUTHOR] Published on 2/4/2021 3:24:00 PMASCPT Webinar Presented by the International Transporter Consortium
Title: Use of Extended Clearance Concept and PBPK Modeling in New Drug Discovery and Development: Predicting Target Tissue Exposure from In Vitro to In Vivo
Date and Time: Wednesday, March 31, 2021, 5:00-6:30 pm ET – This option is at capacity. Please contact members@ascpt.org to be added to the wait list.
Encore Date and Time with All-New Live Q&A: Tuesday, April 6, 2021, 6:00-7:30 pm ET – Register Now!
Speaker: Yuichi Sugiyama, PhD, RIKEN Baton Zone Program
Moderator: Kathy Giacomini, PhD
Description: Join us for a special 90-minute webinar with guest speaker Yuichi Sugiyama, PhD, as he officially kicks off the April 19-21, 2021, International Transporter Consortium Workshop 4. Professor Sugiyama will describe “Extended clearance concept” and show participants how to establish a physiologically- based pharmacokinetic (PBPK) model that includes the transporter-mediated membrane transport and enzyme-mediated metabolism processes. In addition, changes in transporter (influx, efflux) function and metabolizing enzyme function affects the pharmacokinetics of drugs in the blood and the liver and, ultimately, the pharmacological and/or toxicological effects will be discussed. Related to the above-described objectives, the webinar will also cover recent studies on the following three topics.
- Necessity of incorporating albumin-mediated hepatic uptake mechanism to obtain better in vitro/in vivo extrapolation of hepatic clearance.
- Substrate-dependent and/or pre-incubation time dependent Ki values of OATP1B inhibitors.
- Use of endogenous biomarkers to facilitate subject phenotyping and DDI Prediction.
*Note: registration for this special webinar is open and participants are encouraged to register for the International Transporter Consortium Workshop 4 being held April 19-21, 2021.
