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Program Information

WEDNESDAY, MARCH 21, 2018 | 10:00 AM – 5:00 PM

Half-Day Symposium and Mock-team Workshop 
Co-Sponsors: IQ Consortium, Pediatric Working Group, Clinical Pharmacology Leadership Group; and ASCPT Special Populations Community 
A recent paradigm change in pediatric drug development has centered on earlier and more innovative approaches to clinical research in children, with the goal of generating data that can support regulatory approval and/or provide useful information for practitioners in labeling, thereby minimizing the potential risk associated with “off-label” use. This pre-conference session will explore these issues through the lenses of both oncology and Type 2 Diabetes for the pediatric patient.

WEDNESDAY, MARCH 21, 2018 | 1:00 PM – 5:00 PM

Half Day Pre-Conference with Multiple Engaging Lectures and Opportunities for Discussion
Co-Sponsors: ASCPT Quantitative Pharmacology and Development and Regulatory & Outcomes Networks; and International Society for Pharmacoeconomics and Outcomes Research. 

Translation from efficacy in randomized controlled trials (RCT) to real world effectiveness and to cost-effective patient care is an emerging interest and the ultimate goal for clinical pharmacology and therapeutics. Featuring prominent leaders in the fields of clinical pharmacology, outcome research, and pharmacoeconomics, this pre-conference will promote inter-disciplinary collaboration and present state-of-the-art science and application of quantitative approaches at these junctures.

State of the Art Speaker I

Thursday, March 22, 2018, 9:00 - 10:00 AM
Jack Gilbert, PhD
University of Chicago, Chicago, IL
Invisible Influence: The Microbiome in Precision Medicine

State of the Art Speaker II

Friday, March 23, 2018, 9:15 - 10:15 AM
Mara Aspinall, MBA 
Health Catalysts, Tucson, AZ
Data is the New Black: How the Fourth Industrial Revolution is Changing Healthcare

State of the Art Speaker III

Saturday, March 24, 2018, 9:15 - 10:15 AM
Sebastian Schneeweiss, MD, ScD
Harvard Medical School and Brigham and Women's Hospital, Boston, MA
Using Complex Healthcare Databases to Evaluate the Safety and Effectiveness of Newly Marketed Medications

Featured Speaker I

Thursday, March 22, 2018, 11:15 AM - 12:15 PM
Angela Kashuba, PharmD
John & Deborah McNeill, Jr. Distinguished Professor, Director, CFAR Clinical Pharmacology and Analytical Chemistry Core, Adjunct Professor, Infectious Diseases
University of North Carolina Eshelman School of Pharmacy, North Carolina

Featured Speaker II

Friday, March 23, 2018, 1:15 - 2:45 PM
Reverse Translational Studies to Understand Drug-Induced Toxicity
Deanna L. Kroetz, PhD
Professor of Bioengineering and Therapeutic Sciences
University of California, San Francisco

ASCPT is proud to honor the top scoring abstracts submitted by clinical pharmacologists in training. These Presidential Trainee Award recipients will be recognized during the Showcase of Top Trainee Abstracts on Wednesday, March 21 from 5:00 PM- 6:30 PM. Posters will be on display during poster sessions on Wednesday, Thursday, and Friday.

These videos highlight the exceptional research of the Presidential Trainee Award recipients.


Arjun P. Athreya, MS
FACTOR GRAPHS IDENTIFY SEX-SPECIFIC ANTIDEPRESSANT RESPONSE PROFILES: CITALOPRAM/ESCITALOPRAM AS MOLECULAR PROBES FOR SUBGROUPS OF MAJOR DEPRESSIVE DISORDER PATIENTS.
University of Illinois at Urbana-Champaign 
View video
   

Kit Wun Kathy Cheung, PharmD
CHARACTERIZING THE ONTOGENY OF TEN RENAL TRANSPORTERS IN AFRICAN AMERICANS USING QUANTITATIVE PROTEOMICS, GENE EXPRESSION ANALYSIS, AND CLINICAL DATA.
University of California, San Francisco
View video
   

Rachel Dalton, PharmD
A MULTIFACTORIAL CYTOCHROME P450 2D6 GENOTYPE-PHENOTYPE PREDICTION APPROACH TO IMPROVE PRECISION OF CLINICAL PHARMACOGENETIC TEST INTERPRETATION.
University of Montana
View video
   

Jacqueline Gerhart, MS
PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING OF FLUCONAZOLE USING PLASMA AND CEREBROSPINAL FLUID SAMPLES COLLECTED FROM PRETERM AND TERM INFANTS.
UNC Eshelman School of Pharmacy
View video
   

Sophie Gravel, BSc
EFFECTS OF TYPE 2 DIABETES ON DUODENAL CYP450 ACTIVITIES.
University of Montreal – CRCHUM
View video
   

Ming-Fen Ho, PhD
KETAMINE AND KETAMINE METABOLITES AS NOVEL ESTROGEN RECEPTOR LIGANDS: INDUCTION OF CYP2A6, CYP2B6 AND AMPA RECEPTOR —GENOMIC LINKS TO SEX-DIFFERENCES IN KETAMINE RESPONSE.
Mayo Clinic
View video
   

Sarah Kim, PhD
APPLICATION OF A SYSTEMS PHARMACOLOGY APPROACH FOR A DETAILED INVESTIGATION OF AN ADVERSE DRUG REACTION DUE TO DISTINCT MECHANISMS OF IMMUNE CHECKPOINT INHIBITORS.
University of Florida
View video
   

Dea Kojovic, BSc
ELEVATED SFLT-1 IN PRE-ECLAMPSIA IS ASSOCIATED WITH A DOWNREGULATION OF TRANSPORTERS IN HUMAN PLACENTA.
University of Toronto
View video
   

Alix Leblanc, PhD
TARGETING OATP1B2 TO AMELIORATE PACLITAXEL-INDUCED CHRONIC PERIPHERAL NEUROPATHY.
The Ohio State University
View video
   

Stephanie Nicole Liu, PharmD
PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODEL INCORPORATING EXTRAHEPATIC GLUCURONIDATION PREDICTS INTEGRASE INHIBITOR PHARMACOKINETICS.
Indiana University School of Medicine
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Michael Martin, PharmD, PhD
TRANSLATIONAL MODEL OF PYRAZINAMIDE SITE-OF-ACTION PHARMACOKINETIC DISTRIBUTION IN A RABBIT MODEL OF TUBERCULOSIS AND IN TB PATIENTS.
University of California, San Francisco
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Rina Nishii, MS
PRECLINICAL EVALUATION OF NUDT15 GENOTYPE-GUIDED THIOPURINE DOSE INDIVIDUALIZATION USING CRISPR-CAS9 MOUSE MODEL.
St. Jude Children's Research Hospital
View video
   

Jagdeep T. Podichetty, PhD
IMPLEMENTING DATA MINING AND MACHINE LEARNING TECHNIQUES TO DRUG DEVELOPMENT IN SCHIZOPHRENIA.
Indiana University School of Medicine
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Sonal Singh, PhD
TARGETED SEQUENCING IDENTIFIES MISSENSE VARIANT IN THE BEST3 GENE ASSOCIATED WITH ANTIHYPERTENSIVE RESPONSE TO THIAZIDE DIURETICS.
University of Florida
View video
   

D. Max Smith, PharmD
OUTPATIENT CYP2D6 GENOTYPE-SUPPORTED OPIOID THERAPY: A PROSPECTIVE TRIAL.
University of Florida
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Ming-Liang Tan, PhD
PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING OF THE EFFECT OF CHRONIC KIDNEY DISEASE ON THE PHARMACOKINETICS OF NONRENALLY ELIMINATED DRUGS.
US Food and Drug Administration
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Tanaya Vaidya, MS
SYSTEMS PHARMACOLOGICAL ANALYSIS OF A TUMOR PRIMING COMBINATION THERAPY TO OVERCOME HER2 AND MTOR THERAPIES RESISTANCE IN BREAST CANCER.
University of Florida
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Ye Xiong, PhD
IMPROVED PREDICTION OF INFLIXIMAB CLEARANCE USING ERYTHROCYTE SEDIMENTATION RATE AND ANTI-INFLIXIMAB ANTIBODY LEVELS IN PEDIATRIC PATIENTS WITH INFLAMMATORY BOWEL DISEASE.
Cincinnati Children's Hospital Medical Center
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Ling Zou, PhD
INTERACTIONS OF AZO DYES COMMONLY USED IN ORAL DRUG PRODUCTS WITH THE ORGANIC ANION TRANSPORTING PEPTIDE 2B1 AND HUMAN GUT BACTERIA.
University of California, San Francisco
View video
   
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