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Systems Pharmacology (SP) Community

Community Goals

Scientific Expertise
This Community is a resource for best practices in Systems Pharmacology through ‘state-of-the-art’ communication and compendium of current case examples, and through contributions to Annual Meeting programming and educational opportunities.   

Catalyst for Innovation
The Systems Pharmacology Community is implementing a ‘hot topics’ forum listing emerging and novel methods for collaborative Community development. This forum will be hosted on the ASCPT Systems Pharmacology Community site and/or other social media site(s).

Influence and Impact
Our Community is initiating a compendium of clinical systems pharmacology case examples with impact statements describing how each has influenced clinical and/or regulatory-focused decisions. This compilation will include solicitation from the Community members and a literature review with a potential ‘hot topics’ forum as necessary.

Education and Communication
Our Community is developing an inventory of the current ‘state-of-the-art’ in Systems Pharmacology to identify areas of need as training & communication opportunities, e.g., model development and qualification standards. We also continue to develop educational opportunities around subjects identified by members of our Community.  

Organizational Effectiveness
We are establishing a Systems Pharmacology Community Steering Committee (SC) membership along with general roles & expectations necessary to align our contributions with other Community goals. We are also establishing timings for communication outreach to Community members to announce key dates and news updates.

Community News
Please log in as a member to access more Community News and members-only content.

Join the Pharmacometrics Study Group
Do you have lab-meetings and learning tutorials in-house in your academic group, company or your neighborhood? Do you know that not all institutes have the same critical mass of pharmacometric experts as yours? The Pharmacometrics StudyGroups, an iniative of the International Society of Pharmacometrics (ISoP), is a platform to share your learning experiences with peers all around the world. Turn those in-house lab meetings to global knowledge and skill sharing opportunities! Learn more here


Upcoming Webinar
Joint SP and BTT Community Webinar
Title
: Quantitative Systems Pharmacology (QSP) Modeling of Drug-Induced Nephrotoxicity – Bridging the Link Between Drug Exposure, Urinary Biomarkers and Renal Dysfunction, Presented by the BTT and SP Communities
Date and Time: Friday, February 16, 2018, 12:00 pm ET
Speakers: Yeshitila Gebremichael, PhD, Scientist, DILIsym Services., Inc.
Moderators: Richard Graham, PhD, Senior Director, Theravance Biopharma and BTT Community Chair
Description: Drug-induced nephrotoxicity is a challenging problem in both drug development and clinical treatment of critically ill patients. Detecting the potential for nephrotoxicity early in the drug development process is vital for safe development and dosing of therapies. Many novel urinary biomarkers that are injury-specific and more sensitive than traditional biomarkers have been identified recently, whereas interpretation remains challenging. Furthermore, a quantitative framework that links biomarkers signals to underlying cellular injury and renal dysfunction is lacking. Such framework plays a crucial role in safe drug development and clinical treatment. By coupling observations from preclinical urinary biomarkers and histopathology data with cell biology, renal physiology, and the physiologic processes involved in biomarker expression, we developed a multiscale quantitative systems pharmacology (QSP) model of drug-induced acute kidney injury.
Registration Link: https://attendee.gotowebinar.com/register/2375674479891555073
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