Webinar Resources

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Upcoming Webinars

ASCPT Members-Only Webinar presented by the Biologics Community, Pharmacometrics & Pharmacokinetics Community (PMK), Systems Pharmacology Community (SP), and Biomarkers & Translational Tools (BTT) Communities
Title: Clinical Pharmacology Considerations in Development of siRNA Therapeutics: Case Study of Givosiran
Date and Time: Tuesday, April 21, 2020, 1:00 pm ET
Speakers: Sagar Agarwal, PhD and Varun Goel, PhD
Moderator: Sagar Agarwal, PhD
Description: Small interfering RNAs (siRNAs) are a promising type of RNA-based therapeutic oligonucleotide drugs that can inactivate several target RNA molecules in a sequence-specific manner. Since the discovery of RNA interference (RNAi), a significant progress has been made in the development of therapeutic siRNAs including approval of the first ever siRNA therapy. Givosiran is a FDA approved siRNA therapeutic for the treatment of acute hepatic porphyria. Givosiran which is administered subcutaneously utilizes a GalNAc conjugate technology to enable targeted delivery to liver, the site of action. This presentation will give an overview of the clinical pharmacology program of givosiran, that included characterization of the PK and PD of givosiran, the impact of extrinsic and intrinsic factors, as well as special populations. Modeling and simulation analysis that enabled dose selection will be discussed.
Registration Link: hhttps://zoom.us/webinar/register/WN_idlcGg4PRsOVGKc0H3A1Rw

ASCPT Members-Only Webinar presented by the Early Career (EC) Community
Title: Clinical Pharmacology Considerations in the Development of Immune-Oncology Drugs
Date and Time: Thursday, April 30, 2020, 1:00 pm ET
Speaker: Nidal Al-Huniti, PhD
Moderator: Malek Okour, PhD, and Nithya Srinivas, PhD
Description: Building on the success of PD-1 (or PD-L1) inhibitors, a wave of next generation immunotherapies with different mechanisms of action (e.g., LAG3, CD40, ICOS, TIM-3, IDO1, GITR, STING, OX40, TIGIT) are being developed across multiple oncology indications. A key characteristic of immune-oncology programs is the assessment of clinical pharmacology information in patients within safety and efficacy studies, rather than through the use of healthy volunteer studies. As a result of this condensed trajectory of development, unique opportunities exist for the use of modeling and simulation strategies to address several important questions in immune-oncology development - from translation of pre-clinical data into first-in-human studies, to the characterization of relationships between exposure and safety/efficacy in pivotal clinical trials. This webinar will focus on strategies to optimize and highlight immuno-oncology drug development and expand on pharmacometrics, clinical pharmacology and statistical strategies to optimize clinical trial design and development of immune-oncology drugs.
Registration Link: https://zoom.us/webinar/register/WN_ZziZ45ahSci1dMlOumy0bA

Webinar Committee

Mission

To facilitate ASCPT member engagement in the science and practice of clinical pharmacology beyond the Annual Meeting through the development of an ongoing webinar series.

Responsibilities

The ASCPT Webinar Committee is responsible for reviewing, coordinating, and scheduling of select ASCPT Members-Only Webinars. Representatives from each of the three ASCPT Networks are included in the Committee and are charged with facilitating the submission of high-quality proposals from their respective Networks.

Leadership

Kimberly Collins, PhD

Committee Chair

Eric Masson, PharmD

Committee Vice Chair

Antoinette Ajavon-Hartmann, PhD

Committee Past Chair

Committee Members

Kayla Andrews, MS, PharmD, PhD
Matthew Riggs, PhD
Jesse Swen, PharmD, PhD
Rodrigo Cristofeletti, MSc, PhD

Submit a Webinar Proposal

Webinar proposals are received and reviewed by the Webinar Committee on an ongoing basis. Please plan to submit your completed proposal using the form below at least 8 weeks prior to your planned webinar. Note, based on the current Webinar schedule, your desired date(s) may be unavailable, however, the Webinar Committee will review to select alternate options.

Prior to the presentation of the webinar the speaker is requested to complete and return the ASCPT Duplication Recording and Distribution Form to Lisa Infelise (lisa@ascpt.org).