Author: Patty Maglalang, PharmD on April 24, 2024 
With a wide variety of antiseizure medications (ASMs) available and the dynamic nature of children's physiology, ensuring effective therapy could present a challenge. As children grow and change, variables that influence drug disposition do as well. Body weight, age, drug interactions, formulation – these are just a few pieces of the puzzle contributing to pharmacokinetic (PK) variability in children. Maglalang et al. discusses a variety intrinsic and extrinsic factors shaping PK and pharmacodynamic (PD) variability in pediatric ASM therapy and proposes innovative strategies to overcome barriers in drug optimization.
Modeling and simulation can circumvent obstacles posed by traditional clinical studies in the pediatric population. As we navigate through the complexities of pediatric epilepsy management, the review highlights not only current challenges but also promising pathways ahead such as the use of physiologically-based pharmacokinetic modeling, extrapolation of efficacy for ASMs used for focal onset seizures, and the role of artificial intelligence/machine learning in epilepsy management.
Our comprehensive review is available as an Open Access paper.
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