Translational Bytes

Sep12 Understanding and Reducing Cognitive Biases in Healthcare

In the fast-paced world of healthcare, the impact of cognitive biases on decision-making cannot be overstated. “ How Debunking Biases in Research and Development Decisions Could Lead to More Equitable Healthcare? ” by Weber et al . sheds light on the influence of biases in pharmaceutical research...

As of early 2024, data have been collected for more than 5,500 patients with genetic samples available for nearly 2,500 patients. The comprehensive data collection, including from electronic health record reviews and patient interviews, promises to inform studies of real-world effectiveness of geno...

Given the accelerated antimicrobial resistance globally, which caused 1.27 million deaths in 2019, there is an urgent need for efficient methods that can speed up drug development and translate between preclinical and clinical settings. In antimicrobial pharmacokinetics-pharmacodynamics (PKPD), the...

Many drugs that are currently approved in children are initially developed in adults. Adult data is used to inform dosing for pediatric studies through leveraging pharmacokinetic (PK) data such as exposure matching to adults. However, locally acting drugs (LADs) have limited systemic exposure and t...

With a wide variety of antiseizure medications (ASMs) available and the dynamic nature of children's physiology, ensuring effective therapy could present a challenge. As children grow and change, variables that influence drug disposition do as well. Body weight, age, drug interactions, formulation ...

We set out to evaluate the quality and precision of real-world observational studies (RWS) versus randomised controlled trials (RCTs). Any answer we found would have profound impact on the scientific community’s ability to respond quickly and well to future pandemics. With 249 study results from a ...

Looking back at 2023, CTS has had a great year. One of our goals continues to be becoming a beacon for the field of translational science, fulfilling a major component of ASCPT’s Strategic Plan . In the spirit of a 2023 review, we wanted to celebrate our most impactful contributions.

The world of biopharmaceuticals is ever evolving, with groundbreaking drugs constantly being developed to combat a myriad of diseases. Understanding how these drugs work, their pharmacokinetics, and pharmacodynamics is crucial not just for healthcare professionals but especially for anyone with an ...

Dec20 Tutorial on Data Management

In a tutorial from Clinical and Translational Science (CTS) entitled “Data Management 101 for drug developers: A peek behind the curtain”, my coauthors and I review the essentials of clinical data management. This tutorial is mainly for those who are new to drug development and assumes only a passi...

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