Translational Bytes

Jan21 CTS: Ringing in 2025, and Looking Back on a Strong 2024!

Wishing you a new year filled with breakthroughs in translational science! At Clinical and Translational Science ( CTS ), we hope you had a wonderful and relaxing holiday season with your family and friends, and wish you a happy, healthy, and successful 2025.

As the size of the data platforms grows and their relative ease of use improves, so does the potential for error or misinterpretation. It becomes crucial to consider the problems we try to address and whether they are reasonable for the available data and structure. It is critical to distinguish st...

DPP-4 is an endopeptidase widely expressed in organs and tissues, regulating blood glucose by degrading incretin hormones. DPP-4 has two forms: transmembrane DPP-4 (tDPP-4), found on cell membranes, and soluble DPP-4 (sDPP-4), produced by the shedding of tDPP-4 into plasma. tDPP-4 predominates, es...

Voriconazole is used to prevent and treat fungal infections following allogeneic hematopoietic stem cell transplantation. CYP2C19 converts it into inactive metabolites. The CYP2C19 gene is genetically polymorphic resulting in five distinct metabolizers phenotypes: poor (2%), intermediate (IM, 23%),...

Genomic data used for research and clinical care must incorporate all populations, including people from underrepresented groups, to realize the promise of personalized medicine. Thus, diverse datasets are required to fully unlock the power of using genomic information for selection and dosing of d...

In the fast-paced world of healthcare, the impact of cognitive biases on decision-making cannot be overstated. “ How Debunking Biases in Research and Development Decisions Could Lead to More Equitable Healthcare? ” by Weber et al . sheds light on the influence of biases in pharmaceutical research...

As of early 2024, data have been collected for more than 5,500 patients with genetic samples available for nearly 2,500 patients. The comprehensive data collection, including from electronic health record reviews and patient interviews, promises to inform studies of real-world effectiveness of geno...

Given the accelerated antimicrobial resistance globally, which caused 1.27 million deaths in 2019, there is an urgent need for efficient methods that can speed up drug development and translate between preclinical and clinical settings. In antimicrobial pharmacokinetics-pharmacodynamics (PKPD), the...

Many drugs that are currently approved in children are initially developed in adults. Adult data is used to inform dosing for pediatric studies through leveraging pharmacokinetic (PK) data such as exposure matching to adults. However, locally acting drugs (LADs) have limited systemic exposure and t...

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