Translational Bytes

Sep16 Dishing Out the QT Risk

Early identification of QT-prolongation or pro-arrhythmic risk for drugs in development has historically relied on binding or functional assays for hERG and other ion channels, with follow-up studies in animals. This hERG-to-animal approach entails a jump from simple and relatively uncertain to cos...

Historically, cancer detection and drug response monitoring required collecting tumor biopsies, which can be a very invasive procedure, to characterize many types of solid tumors such as non-small cell lung cancer (NSCLC), and is practically infeasible for many others. Furthermore, given their inva...

A recent publication in CTS by Lyauk et al . presents results from an evaluation of dose selection in NDAs approved by the FDA between 2015 and 2017, in an effort to characterize the extent to which sponsors follow the “learn and confirm” paradigm of dose selection.

The most recent impact factor (IF) numbers are in, and Clinical and Translational Science (CTS) has again doubled its IF to 3.989. The 2018 IF is the first year that we “own” the entire metric. Last year, we owned half the 2017 metric and the IF was 1.954, while two years ago, the old editori...

Jul12 The Difference Is Night and Day

Does your study call for recurrent measurement of heart rate or blood pressure? If so, read “ Models of Variability and Circadian Rhythm in Heart Rate, Blood Pressure, and QT Interval for Healthy Subjects Who Received Placebo in Phase I Trials ” by Mukul Minocha et al . In this creative appr...

Jun14 Children Are Not Little Adults

There is a saying in experimental pharmacology that preclinical species are not little humans. In clinical pharmacology, the same sentiment is true for pediatric populations. You do not need to be a parent or a pediatrician to realize that children are not just mini versions of adults. Yet a common...

May20 The ABCs of INDs and CTAs

As part of CTS ’s continued commitment to providing practical, open access tutorials on tools, methodologies, and approaches in translational medicine, the CTS editorial team is delighted to highlight the first in a series of Regulatory Affairs tutorials. The tutorial, “ Regulatory A...

May10 Brief Is Beautiful

In January 2017 Clinical and Translational Science launched the Brief Reports article category . This article type was intended for publication of short-format papers that describe significant novel research findings in translational sciences. During the first four months of 2019 we have seen au...

Congratulations to the American Society for Clinical Pharmacology and Therapeutics (ASCPT) , Dan Hartman, MD, President, the Scientific Program Committee, chaired by Piet van der Graaf, PhD, PharmD, and all of the speakers, contributors, exhibitors, staff, and attendees for a fantastic 2019 Annu...

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