Translational Bytes

Jul21 CTS Refreshes Our Aim and Scope

Clinical and Translational Science ( CTS ), an official journal of the American Society for Clinical Pharmacology and Therapeutics, has refreshed and refined our aim and scope , aligned with the translational approach of the National Center for Advancing Translational Sciences (NCATS) ...

Pharmacoepidemiological studies often ask big questions of big databases that can inform risk/benefit conversations at the be d side such as "What is the association of X outcome in individuals who were exposed to Y drug?"

May20 Age Matters in Precision Medicine

Using genetic test results to guide drug therapy (pharmacogenetics) is a cornerstone for the growing field of precision medicine. This approach has been implemented by some medical centers for an array of medications where the association between genetic variation and drug response has been well-es...

As part of a course on vaccine development, students are exposed to the phases of vaccine development focused on R&D activities, timing, and cost considerations as well as key features that are distinctly different from drug development. Additional activities and nuances such as the use of global b...

Among the many efforts to improve productivity in drug development are Phase-0 approaches that use sub-therapeutic exposures in First-in-Human (FIH) studies. The low exposures and the implied safety allow reduced regulatory packages and entry into human testing earlier and with fewer resources than...

Young Huh and colleagues adapted and piloted blockchain technology in a decentralized clinical trial platform to facilitate rapid dissemination of protocol changes, efficient participant reconsenting and real-time monitoring of procedure adherence, all done remotely. Their article is intriguing and...

We are excited by the prospects for the 2022 ASCPT Annual Meeting , which is ongoing this week. Every year, the Clinical and Translational Science ( CTS ) Editorial Team has the opportunity and privilege to present a CTS Award at the ASCPT Annual Meeting. This year, we have chosen ...

Mar01 To Blind or Not to Blind

To blind or not to blind – that is the question asked my numerous scientists across multiple stakeholders, particularly with regard to early clinical phase 1 studies. Many authors have opined for or against blinding in various phase 1 settings, but an IQ Consortium working group recently completed ...

Feb07 Pharmacist Test Thyself?

As implementation of pharmacogenetic testing increases across the world, a major limitation remains the education and resources available for healthcare professionals. This push towards implementation presents an opportunity for pharmacists to be leaders in this area. Consequently, there has been a...

Happy New Year from Clinical and Translational Science ( CTS )! Looking back, CTS has celebrated much success in 2021. Our goal continues to be becoming a beacon for the field of translational science, fulfilling a major component of ASCPT’s strategic plan.

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