Translational Bytes

Feb03 Bench to Bedside at CTS: 2025 Year in Review

2025 was a complex and challenging year for science (and the world), but for CTS it was auspicious. 2025 by the numbers was a good one. One of our key objectives continued to be becoming a beacon for the field of translational science. Growth of CTS since we relaunched as an ASCPT journal in 20...

Indomethacin is the 10 th most commonly used medication in Neonatal Intensive Care Units (NICU) for two conditions: intraventricular hemorrhage (IVH) and patent ductus arteriosus (PDA); however, current dosing has not been evidence-based. Standard weight-based dosing often leads to unpredictable c...

The newly released Biomedical Data Translator represents a groundbreaking step forward in bridging fragmented biomedical data sources into a cohesive, user-friendly research tool. Translator integrates disparate datasets — ranging from clinical and genomic to pharmacologic and more — into a scala...

Therapeutics for B-cell non-Hodgkin lymphoma (B-NHL) have advanced over recent decades, with immunotherapies taking a central role in the evolving treatment paradigm. Bispecific antibodies (bsAbs) that engage T cells (via CD3) and malignant B cells (via CD20), including four CD20×CD3 bsAbs (mosunet...

Are you involved in drug development for therapeutic peptides—whether in DMPK, clinical pharmacology, or other related disciplines? Are you unsure of how the development program differs from your standard small molecule projects? In 2023, we published an industry position paper , which was the fir...

Voriconazole (VRCZ) is a potent antifungal agent used to treat invasive fungal infections. However, its clinical utility is limited by the large inter-individual variability in blood concentrations and narrow therapeutic window, which contributes to toxicity and treatment failure. A key factor is g...

With school, college, and university Fall semesters underway, we reflect on the 2025 Clinical and Translational Science ( CTS ) journal award. Every year, the CTS Editorial Team has the opportunity to present a CTS award, typically at the annual meeting of the American Society for Clinical Ph...

Clear and standardized terminology is essential for the effective communication and adoption of emerging technologies. To address this need in the field of liquid biopsy, The Blood Profiling Atlas in Cancer (BLOODPAC) Consortium has developed a comprehensive lexicon for circulating tumor DNA (ctDN...

Identifying cardiovascular (CV) risks early in drug development is essential, especially for detecting arrhythmias and hemodynamic changes. Despite this, many nonclinical toxicology studies still rely on brief, restraint-based ECG and blood pressure measurements that often miss the timing of peak d...

Large language models (LLMs), like ChatGPT, are no longer just tech-world curiosities; they’re increasingly making their way into drug discovery and clinical development. In this new Clinical and Translational Science primer article , the authors walk through how LLM models work, what makes them...

Page:

of 19