Mar09 There Is No Such Thing as Failure
I obtained my medical training before any formal training in research. My observations (and frustrations ) of variability in patient drug response is what sparked my interest in therapeutics research in the first place, and what continues to motivate me as an investigator and a physician-scienti... Read More..
Feb20 Pharmacokinetics on Bugs
It has been a bit over a 100 years since Professor Alfred Nissle, in Freiburg, Germany, had students mix their own stools with pure cultures of pathogenic Salmonella strains in practical courses to discover that while Salmonella usually prevailed in the cultures, in some cases the students’ ... Read More..
Feb09 Real Time for Zika: Why Reverse Translation Resonates with Non-Scientists
A common complaint I hear from non-scientists is that they don’t understand research. “It’s way over my head,” they say. Or, “This research has nothing to do with me or my life. So, why should I care?” This disconnect between what’s perceived as important research topics by the community and the re... Read More..
Jan24 The Future Is Not Linear
A Multidimensional Roadmap for Improving Therapeutic Development
Raise your hand if you have been in a classroom or symposium in the past year where the all too familiar ‘chevron diagram’ of the therapeutic development process has been shown! This step-by-step linear process for therapeutic d... Read More..
Jan10 Precision Dosing – Current Status, Future Impact
With the continued advancement and expansion of pharmacogenetics testing into clinical practice, the widespread adoption of electronic health record (EHR) systems in hospitals and other clinical research centers, and the development of PKPD models to guide, model-informed dosing, there has been sig... Read More..
Dec29 2017 Downloads and Attention at Clinical and Translational Science
The vision for Clinical and Translational Science ( CTS ) is to become the beacon and organizing principle for the field of translational medicine, as well as to provide a vehicle for ASCPT member publications. This vision is well-aligned with the 2015-2020 ASCPT Strategic Plan asserting that the... Read More..
Dec11 The Success Story of the Critical Path and Public-Private Partnerships
Since 2004 when the US Food and Drug Administration (FDA) launched
the Critical Path Initiative (CPI), a gap was filled that has aided
research translation. The Critical Path Opportunities List addressed
many of the specific priorities and identified needs, and was published
for the Initiative ... Read More..
Nov16 Get Smart(er)
Nov01 Eating Olives Increases Plasma Catechols, so Does My Martini Have Health Benefits?
Eating olives has been implicated with a plethora of health benefits including cardiovascular benefits, cancer prevention, antioxidant effects, and many others. In addition to being found in martinis, olives are an important component of the Mediterranean diet. In fact, the catechol dihydroxyphenyl... Read More..
Oct20 Patient Enrichment Strategies for Accelerated Drug Approval
Oncology drug development has pioneered the use of biomarker-driven patient selection for clinical trials, and other therapeutic areas would benefit from similar approaches. Novel therapeutics that target a specific mutation(s) in a gene or set of genes in a critical signaling pathway, or that targ... Read More..