Translational Bytes

Apr24 Drug Variability in Pediatric Epilepsy Treatment

With a wide variety of antiseizure medications (ASMs) available and the dynamic nature of children's physiology, ensuring effective therapy could present a challenge. As children grow and change, variables that influence drug disposition do as well. Body weight, age, drug interactions, formulation ...

We set out to evaluate the quality and precision of real-world observational studies (RWS) versus randomised controlled trials (RCTs). Any answer we found would have profound impact on the scientific community’s ability to respond quickly and well to future pandemics. With 249 study results from a ...

Looking back at 2023, CTS has had a great year. One of our goals continues to be becoming a beacon for the field of translational science, fulfilling a major component of ASCPT’s Strategic Plan . In the spirit of a 2023 review, we wanted to celebrate our most impactful contributions.

The world of biopharmaceuticals is ever evolving, with groundbreaking drugs constantly being developed to combat a myriad of diseases. Understanding how these drugs work, their pharmacokinetics, and pharmacodynamics is crucial not just for healthcare professionals but especially for anyone with an ...

Dec20 Tutorial on Data Management

In a tutorial from Clinical and Translational Science (CTS) entitled “Data Management 101 for drug developers: A peek behind the curtain”, my coauthors and I review the essentials of clinical data management. This tutorial is mainly for those who are new to drug development and assumes only a passi...

In a recent article published in Clinical and Translational Science , Dhaenens et al. reported the results of a collaboration between two Innovative Medicines Initiative (IMI(2)) projects: the Collaborative Network for European Clinical Trials for Children (conect4children, c4c) project...

Nov20 Dexamethasone PK/PD in COVID-19

Dexamethasone has become an important element of COVID-19 treatment in patients requiring oxygen therapy. Our research reveals that daily doses of 6 or 12 mg dexamethasone for 10 days are required for substantial reductions in TNFα, IL-6, and CRP concentrations. This study not only reaffirms the cu...

Clopidogrel, a widely prescribed antiplatelet medication, varies in its effectiveness due to multiple factors, including genetics and drug interactions. The CYP2C19 enzyme plays a key role in converting clopidogrel into its active form. Individuals carrying CYP2C19 loss-of-function (LOF) allele...

Oct16 Not Allergic to Immunotherapy

Allergic conditions such as asthma, chronic urticaria, atopic dermatitis, and eosinophilic esophagitis are widespread among the population. Often patients will have multiple concomitant allergic conditions, each requiring its own management strategy and specialist visits. During the last few decade...

Employing fit-for-purpose biomarkers in the earliest phases of drug development can advance rational clinical development of drug candidates. Identifying the right biomarker(s) for this task is crucial, especially in mitochondrial disorders—diseases characterized by substantial heterogeneity, both ...

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