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Translational Bytes

Translational Bytes


Jun30 Initial Clinical Pharmacology Profile of Remdesivir

The battle against the COVID-19 pandemic continues as infections rise in the US and the world. As of June 30, 2020, COVID-19 has plagued the world with  more than 10 million confirmed infections  and more than 500,000 deaths. Patients afflicted with severe COVID-19 are sorely in need of effective...
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Jun04 Can Big Data Improve Generalizability of Study Findings?

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May06 The Burden of Infectious Disease Is Truly Global in the Era of COVID-19

We have seen a mobilization of the biomedical research community to tackle the COVID-19 pandemic like perhaps no other in our lifetimes. What has been remarkable is the pace at which research findings have become available in Open Access and pre-review formats. In their article in  Clinical and Tr...
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Mar26 Clinical Pharmacology to the Rescue for COVID-19 Candidate Therapeutics

As the COVID-19 pandemic takes the world by storm, the search for potential therapeutics ramps up. As of March 26, 2020, COVID-19 has plagued the world with  more than 480,000 confirmed infections and 22,000 deaths . The role for therapeutics could be crucial in stemming morbidity and mortality d...
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Mar17 Multigene Genotyping Panels: More Bang for Your Buck?

Pharmacogene genotyping is almost always reactionary and triggered by the prescribing of an actionable drug. A barrier to pharmacogenetic clinical implementation in the context of reactionary genotyping are delays in the turnaround of genetic data to prescribers. Many experts have argued that preem...
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Mar09 The Great Ranitidine Debate

Cancer. Carcinogen. Malignancy .  These are scary words for a patient to hear, particularly when they refer to the risk of a drug prescribed for the treatment of a relatively benign condition.
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Feb07 Taking Aim at Global Pandemics Using 21st Century Tools

On the last day of 1927, a 30-year-old mother died after two years of consumption that followed the birth of her third child. A year and a half earlier, her younger brother had passed away similarly, and four years earlier another one of her teenage brothers had died. Despite close care from family...
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Jan28 CYP2D6 Genotype to Phenotype: A Global Consensus

The gene encoding CYP2D6 is highly polymorphic, which results in highly variable enzyme activity. Genotype-inferred phenotypes range from poor metabolism to ultra-rapid metabolism depending on the combination of functional and non-functional alleles/haplotypes present. However, regional or institut...
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Jan15 2019 in the Rear-view Mirror, 2020 In-focus!

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Dec26 Trust Your Gut

A recent publication in Clinical and Translational Science (CTS) by Daar et al. presents the results of a pilot study exploring the acceptability of the Proteus Digital Health Feedback (PDHF) system for antiretroviral drugs.
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Recent News
  • ASCPT Members-Only Webinar Presented by the Pharmacometrics & Pharmacokinetics (PMK) Communities Members-Only Webinar
    September 17, 2020
  • Special ASCPT News: Call for ASCPT Journal Family Editors-in-Training
    September 17, 2020
  • Who’s Influencing Patients When They Can’t Understand What We’re Saying?
    September 16, 2020
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