Translational Bytes

May06 The Burden of Infectious Disease Is Truly Global in the Era of COVID-19

We have seen a mobilization of the biomedical research community to tackle the COVID-19 pandemic like perhaps no other in our lifetimes. What has been remarkable is the pace at which research findings have become available in Open Access and pre-review formats. In their article in Clinical and Tr...

As the COVID-19 pandemic takes the world by storm, the search for potential therapeutics ramps up. As of March 26, 2020, COVID-19 has plagued the world with more than 480,000 confirmed infections and 22,000 deaths . The role for therapeutics could be crucial in stemming morbidity and mortality d...

Pharmacogene genotyping is almost always reactionary and triggered by the prescribing of an actionable drug. A barrier to pharmacogenetic clinical implementation in the context of reactionary genotyping are delays in the turnaround of genetic data to prescribers. Many experts have argued that preem...

Mar09 The Great Ranitidine Debate

Cancer. Carcinogen. Malignancy . These are scary words for a patient to hear, particularly when they refer to the risk of a drug prescribed for the treatment of a relatively benign condition.

On the last day of 1927, a 30-year-old mother died after two years of consumption that followed the birth of her third child. A year and a half earlier, her younger brother had passed away similarly, and four years earlier another one of her teenage brothers had died. Despite close care from family...

The gene encoding CYP2D6 is highly polymorphic, which results in highly variable enzyme activity. Genotype-inferred phenotypes range from poor metabolism to ultra-rapid metabolism depending on the combination of functional and non-functional alleles/haplotypes present. However, regional or institut...

Dec26 Trust Your Gut

A recent publication in Clinical and Translational Science (CTS) by Daar et al. presents the results of a pilot study exploring the acceptability of the Proteus Digital Health Feedback (PDHF) system for antiretroviral drugs.

Until recently, if you had asked me, “What is the most common eating disorder in the United States?” I would have said Anorexia Nervosa. Or maybe Bulimia? And I would have been wrong. It’s Binge Eating Disorder, a major comorbidity in obesity.

After decades of discovery and translational research into genetic determinants of loss of efficacy and increased toxicity, the pharmacogenetics (PGx) field has set its eyes on implementation of important findings. Groups such as the Clinical Pharmacogenetics Implementation Consortium (CPIC) have p...

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