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Translational Bytes

Translational Bytes


Jun20 Smartwatches: Monitoring Improved Health Awareness in Clinical Trials? ... If Used!

Digital Health Technologies (DHTs: comprising mobile applications, wearables, smart internet-connected devices) have the potential to inform patients’ functioning through remotely collected measurements and transform clinical trials with decentralized operations. Despite the strong potential, the e...
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Jun12 Designing Resource Cognizant Investigator Initiated Clinical Trials: A Tutorial

There remains a critical need to develop therapies for many diseases that currently lack treatments. This need is underscored by an appreciation that drug development, in general, has a high attrition rate, rising costs, and increased delay in bringing treatments to market. Investigator-sponsored c...
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May20 Machine Learning to Improve Speed and Quality of Drug Development?

While machine learning (ML)-based predictions for in vitro ADME assays (absorption, distribution, metabolism, excretion) and noncompartmental analysis (NCA) based pharmacokinetics (PK) parameters are well established to prioritize compounds, the prediction of full plasma concentration time profil...
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May06 Large Language Models to Support Research on Clinical Trial Registries?

There is growing interest in using large language models (LLMs) to support clinical research. In particular, research on clinical trial registries has traditionally required considerable manual curation of data, which has hindered timely and up-to-date investigations on various topics. We hypothesi...
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Apr30 Intranasal Insulin: Emerging Treatment to Reduce Neurological Insult?

Intranasal insulin may have a use as a neuroprotective treatment for a multitude of diseases ranging from cardiac arrest to traumatic brain injury to Alzheimer’s disease. Animal data suggests that high doses of insulin may be required for neuroprotective effects. Current neuroprotective treatments ...
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Apr16 Understanding the Pharmacokinetics of Delta-9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD) Using Physiologically Based Pharmacokinetic Models

The use of cannabis has rapidly increased over the past decade. Understanding how the body processes cannabinoids like THC and CBD is critical for optimizing their safety and medical use. Both compounds undergo first-pass metabolism, primarily through cytochrome P450 (CYP) enzymes and UDP-glucurono...
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Mar25 Detecting NAFLD and NASH via Algorithm

Identification and stratification of patients with under-recognized metabolic disease is critical in addressing the Nonalcoholic Fatty Liver Disease (NAFLD)* public health crisis. Reliance on frontline healthcare recognition alone may contribute to delays in treatment, monitoring, and referrals for...
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Mar17 Common Language for Cancer Detection Technology!

Early detection has been instrumental in reducing cancer mortality rates. With that, there has been a surge in the development of single-cancer detection (SCD) and multi-cancer detection (MCD) testing technology. In a rapidly evolving field, ensuring that all stakeholders are using consistent langu...
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Feb20 What If You Could Experiment on Your Electronic Self?

What is a digital twin? Imagine having a digital mechanistic model-based replica of a patient, enabling you to simulate various treatments and predict their outcomes – your “digital twin.” This powerful concept allows for personalized medicine by mirroring the patient's unique biology and ch...
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Feb06 Application of Modeling and Simulation for In Vivo CAR-Ts to Inform Dose and Regimen Selection

In vivo programming of endogenous T-cells to induce transient CAR-expression ( in vivo CAR-Ts) could be a potential alternative to exogenously administered autologous and allogeneic cell therapies, which inherently possess several limitations such as logistical/financial constraints and graft v...
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Recent News
  • Smartwatches: Monitoring Improved Health Awareness in Clinical Trials? ... If Used!
    June 20, 2025
  • FDA News: Issue 2, June 2025
    June 20, 2025
  • Designing Resource Cognizant Investigator Initiated Clinical Trials: A Tutorial
    June 12, 2025
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