Translational Bytes

Nov20 Dexamethasone PK/PD in COVID-19

Dexamethasone has become an important element of COVID-19 treatment in patients requiring oxygen therapy. Our research reveals that daily doses of 6 or 12 mg dexamethasone for 10 days are required for substantial reductions in TNFα, IL-6, and CRP concentrations. This study not only reaffirms the cu...

Clopidogrel, a widely prescribed antiplatelet medication, varies in its effectiveness due to multiple factors, including genetics and drug interactions. The CYP2C19 enzyme plays a key role in converting clopidogrel into its active form. Individuals carrying CYP2C19 loss-of-function (LOF) allele...

Oct16 Not Allergic to Immunotherapy

Allergic conditions such as asthma, chronic urticaria, atopic dermatitis, and eosinophilic esophagitis are widespread among the population. Often patients will have multiple concomitant allergic conditions, each requiring its own management strategy and specialist visits. During the last few decade...

Employing fit-for-purpose biomarkers in the earliest phases of drug development can advance rational clinical development of drug candidates. Identifying the right biomarker(s) for this task is crucial, especially in mitochondrial disorders—diseases characterized by substantial heterogeneity, both ...

In a recent review in Clinical and Translational Science ( CTS ), Julie Bøttern and colleagues aimed at mapping the current state of sex, ethnic, and racial diversity in clinical trials. They reviewed all papers of clinical trials published in CTS or Clinical Pharmacology & Therap...

In recent years, we have observed an upswing in the use of natural products (NPs) for complementary health. This surge in popularity is often linked to the perception of NPs as safe and natural alternatives. Kratom, one such product, has become widely available in the United States. The American Kr...

Despite multiple available therapies, many patients with asthma still have symptoms that are not well controlled. Most current therapies for asthma target mediators of type 2 inflammation (e.g., interleukins), but these therapies do not provide adequate relief for many patients with type 2-independ...

There is a high prevalence of mental illness and substantial utilization of psychoactive prescription drugs (including antidepressants) among Americans. Given the bidirectional relationship between mental illness and other chronic medical conditions, it is very common for persons with a mental illn...

Federal funding is great, but it takes more than money to translate innovative research ideas into the clinic where they can impact public health. The National Cancer Institute's Small Business Innovation Research Development Center (NCI SBIR) supports the commercialization of novel cancer-related ...

Apr19 Drugs and Bugs

Clinical pharmacology is often viewed as what a drug does to the body and what the body does to a drug. On and in our bodies is a universe of microbes, and each microorganism has its own cellular machinery that can interact with drugs, too. However, the trillions of cells that make up an in...

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