Jun21 The Forecast Is Good for Single Cell Multiparameter Systems
When we look at the weather report, it never simply says “the U.S. is hot today.” Geography matters. We always get some nuances such as temperature, humidity, barometric pressure, chance of rain, air quality, and so on. These patterns are mapped down to the level of the nearest weather station, and... Read More..
Jun06 Beware Bad Journals
One of the challenges facing researchers today is detecting the right journal for your paper. The explosion of new, online-only journals, mostly Open Access, many with names that are confusingly similar to established journals of good repute, has created a landscape that is difficult to navigate. Read More..
May11 How Do You Figure?
The phrase “a picture speaks a thousand words” is often used to describe the impact of a touching photograph, illustration or painting that holds meaning to almost everyone that views it. Why should this not also be true for figures in scientific publications and presentations? Read More..
Apr17 PEG vs. Anti-PEG
Sometimes you run experiments or smaller clinical studies with intriguing results that stand on their own, and other times you have extra material because you just can’t squeeze it all within the word and figure limits of your seminal publication. " Brief Reports" in Clinical and Transl... Read More..
Apr06 Abundant Translational Medicine at the 2018 ASCPT Annual Meeting
Congratulations to the American Society for Clinical Pharmacology and Therapeutics (ASCPT), President Kellie Schoolar Reynolds, PharmD, the Scientific Program Committee, chaired by Peter H. O’Donnell, MD, and all of the speakers, contributors, exhibitors, staff, and attendees for a fantastic 2018 A... Read More..
Mar23 It’s All About the Dose - Current Status and Future Opportunities for Dose Finding in Oncology
In a recent Review published in Clinical and Translational Science ( CTS ) , Ji and colleagues provide an excellent summary of the recent progress and future opportunities, as well as challenges in determining the optimal dose for oncology and immuno-oncology therapeutics. While the approaches... Read More..
Mar09 There Is No Such Thing as Failure
I obtained my medical training before any formal training in research. My observations (and frustrations ) of variability in patient drug response is what sparked my interest in therapeutics research in the first place, and what continues to motivate me as an investigator and a physician-scienti... Read More..
Feb20 Pharmacokinetics on Bugs
It has been a bit over a 100 years since Professor Alfred Nissle, in Freiburg, Germany, had students mix their own stools with pure cultures of pathogenic Salmonella strains in practical courses to discover that while Salmonella usually prevailed in the cultures, in some cases the students’ ... Read More..
Feb09 Real Time for Zika: Why Reverse Translation Resonates with Non-Scientists
A common complaint I hear from non-scientists is that they don’t understand research. “It’s way over my head,” they say. Or, “This research has nothing to do with me or my life. So, why should I care?” This disconnect between what’s perceived as important research topics by the community and the re... Read More..
Jan24 The Future Is Not Linear
A Multidimensional Roadmap for Improving Therapeutic Development
Raise your hand if you have been in a classroom or symposium in the past year where the all too familiar ‘chevron diagram’ of the therapeutic development process has been shown! This step-by-step linear process for therapeutic d... Read More..