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Translational Bytes

Translational Bytes


Sep10 Imaging the 510(k) Diagnostic Approval Process

Biomarkers and diagnostics are a key focus of  Clinical and Translational Sciences (CTS) . Biomarkers are the “glue” and common language of translational medicine, and are enjoying a renaissance of increased cross-stakeholder interest. The surge of work in the field of biomarkers include acti...
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Aug22 Safety Signal or Chance Finding in First-in-Human? There’s a Model for That!

A recurring challenge in early drug development is the interpretation of emerging safety data from first-in-human (FIH) studies, where typical dose escalation for a novel small molecule follows a 6+2 paradigm, whereby 8 subjects (6 active, 2 placebo) are dosed in each ascending dose cohort.   Eme...
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Aug09 The Very Variable Metabolism of the Big T

The effects of testosterone, the big T, and a testis-derived substance driving male characteristics have been known since antiquity, as farmers knew the effects of castration on decreasing aggression and increasing body weight. Not surprisingly, the path to the discovery of testosterone and solving...
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Jul18 CTS Impact Factor More Than Doubles to 1.954!

The most recent impact factor (IF) numbers are in, and  Clinical and Translational Science (CTS)  is clocking in at 1.954, a more than 2-fold increase over the previous year.    Simply stated, the IF is a way of assessing journal performance by calculating how often researchers cite journal p...
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Jul03 Plug and Play for Clinical Data Sharing

Have you traveled internationally recently? If you have, I’m sure you’ve had to lug around an electrical adaptor or two to recharge your devices. Why? Because the world does not have one standard for electrical plugs. Can you imagine how convenient it would be if there was one worldwide standard? N...
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Jun21 The Forecast Is Good for Single Cell Multiparameter Systems

When we look at the weather report, it never simply says “the U.S. is hot today.” Geography matters. We always get some nuances such as temperature, humidity, barometric pressure, chance of rain, air quality, and so on. These patterns are mapped down to the level of the nearest weather station, and...
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Jun06 Beware Bad Journals

One of the challenges facing researchers today is detecting the right journal for your paper. The explosion of new, online-only journals, mostly Open Access, many with names that are confusingly similar to established journals of good repute, has created a landscape that is difficult to navigate. 
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May11 How Do You Figure?

The phrase “a picture speaks a thousand words” is often used to describe the impact of a touching photograph, illustration or painting that holds meaning to almost everyone that views it. Why should this not also be true for figures in scientific publications and presentations?
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Apr17 PEG vs. Anti-PEG

Sometimes you run experiments or smaller clinical studies with intriguing results that stand on their own, and other times you have extra material because you just can’t squeeze it all within the word and figure limits of your seminal publication.  " Brief   Reports"  in  Clinical and Transl...
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Apr06 Abundant Translational Medicine at the 2018 ASCPT Annual Meeting

Congratulations to the American Society for Clinical Pharmacology and Therapeutics (ASCPT), President Kellie Schoolar Reynolds, PharmD, the Scientific Program Committee, chaired by Peter H. O’Donnell, MD, and all of the speakers, contributors, exhibitors, staff, and attendees for a fantastic 2018 A...
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